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Rapid weight loss from GLP-1 medicines like Mounjaro, Zepbound, Ozempic, and Wegovy can lead to loss of cheek volume and early skin sagging (“Ozempic face”). Volume can be restored with hyaluronic acid fillers, newer fillers that may help the body create its own fat, or PRP made from your own blood. Sagging is addressed with non-surgical skin-tightening devices, including radiofrequency and ultrasound treatments.
Ozempic face: A nickname for facial changes—like volume loss in the cheeks and skin sagging—that can appear after significant weight loss on GLP-1–type medications.
GLP-1 agonists: A class of medications that can aid weight loss; examples mentioned include Mounjaro, Zepbound, Ozempic, and Wegovy.
Mounjaro: One of the GLP-1–type medicines mentioned that can lead to weight loss and associated facial volume changes.
Zepbound: A GLP-1–type weight-loss medicine mentioned as an example associated with facial changes from weight loss.
Ozempic: A GLP-1–type medicine mentioned that can lead to weight loss and potential facial volume loss.
Wegovy: A GLP-1–type weight-loss medicine mentioned among the examples.
Hyaluronic acid fillers: Gel-like injectable fillers used for decades to restore lost facial volume, especially in the cheeks.
New fillers that can create fat: Injectable treatments described as helping the body generate its own fat in the treated area to restore volume.
PRP (platelet-rich plasma): A treatment made from a person’s own blood, concentrated in platelets, that can be used as a filler to help restore facial volume.
Radiofrequency devices: Energy-based treatments that use radiofrequency to help tighten sagging skin without surgery.
Ultrasound devices: Energy-based treatments that use focused ultrasound to tighten skin without surgery.