Intrauterine insemination (IUI) for unexplained infertility can increase the chance of pregnancy compared to natural intercourse. While couples just starting to try have a 20-25% monthly pregnancy chance, this drops to 2-3% after 12 months of unsuccessful attempts. IUI can elevate this to approximately 10% per attempt. It is a relatively simple method that facilitates in vivo fertilization. However, a significant drawback is its low success rate, meaning it often does not result in pregnancy. After a certain number of failed IUI cycles, typically an arbitrarily set number, it becomes advisable to explore alternative fertility treatments.