Unexplained infertility is a diagnosis of exclusion, assigned when no underlying cause is identified after comprehensive evaluation of male and female fertility factors. This condition affects 20-30% of patients seeking treatment. Historically, many non-beneficial diagnostic tests were employed, but current medical practice focuses on a core set of effective assessments. When these standard tests yield normal results, treatment strategies for unexplained infertility are discussed, drawing from empirical research. These options typically include timed intercourse, intrauterine insemination (IUI), and in vitro fertilization (IVF). The choice of treatment is individualized, considering the success rates, potential risks, and financial implications of each method.